Fosfomycin Sodium
Synonyms: phosphomycin disodium salt
CAS: 26016-99-9
EINECS: 247-409-2
Assay: 99% min.
Standard: EP/BP/USP
Packing: 25Kg/cardboard drum
Character: Room temperature a white crystalline powder, hygroscopic, easily soluble in water, dissolution heat.
Usage: Disodium Phosphonomycin is a broad-spectrum antibiotics, Mainly used for chickens, ducks, pigs, staphylococcus, streptococcus, E. coli, Salmonella and other gram-negative bacteria cause acute and chronic intestinal diseases.
For the treatment of intestinal infection, with β-lactams, aminoglycosides in combination.
For the treatment of respiratory and lung infections, with macrolides, β-lactam combination.
For Staphylococcus aureus infection cure, should be with erythromycin, rifampin combination.
For the treatment of severe respiratory tract infections, sepsis, peritonitis, etc. to increase the dose. Need and β-lactam or aminoglycoside combination.
1. Antibacterial spectrum, bioavailability, faster absorption, antimicrobial and strong, not diet affected. Against Gram-positive bacteria, negative bacteria have a role in the killing, especially Pseudomonas aeruginosa, Proteus, Salmonella, and a variety of pharmaceutical resistant Staphylococcus aureus and E. coli are able to show excellent antibacterial activity. For animals, there is no resistance and cross-resistance, good clinical outcomes.
2. Bactericidal quickly: This is a fast fungicides, and its role in the 1-2 hours later is already evident. About 25% of E. coli in contact with fosfomycin (12.5μg/ml) was 1 hour after the killing, and all died within 4-6 hours. Pseudomonas aeruginosa and Staphylococcus aureus were also at 4 and 8 hours were all killed.
3. Low toxicity, irritation on the body, does not have acute toxicity and adverse reactions, without increasing the burden on the kidneys.
4. residue: in the muscles and organs to achieve the elimination of residual standard time is 48-72 hours.
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